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Home Lifestyle Health

Breakthrough vaccine could eradicate breast cancer, shows 75% immune response in trial

June 7, 2025
in Health, News
Breakthrough vaccine could   eradicate breast cancer, shows 75% immune response in trial
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The most common cancer in women — and one of the deadliest — may have finally met its match.

Development of a breakthrough vaccine researchers say could eradicate breast cancer by 2030 wrapped up phase one of its clinical trial this week, with more than 75% of women showing a strong immune response, as measured by antibodies on their white blood cells.

The vaccine is aimed at both preventing and treating breast cancer — which affects one in eight women.

A gloved hand preparing a breast cancer vaccine.
The vaccine, funded by the US Department of Defense, has been in the works for years. Courtesy of Cleveland Clinic

“It’s very exciting,” said Dr. Amit Kumar, CEO of Anixa Biosciences, which is designing the vaccine along with the Cleveland Clinic.

During the trial’s first phase, researchers gave the vaccine to 35 women, most of them with triple negative breast cancer — the most lethal form. It’s the type that famously led Angelina Jolie to undergo a preventative double mastectomy at 37, after finding out she had the genetic mutation for the disease.

The women had their blood drawn periodically to measure the level of antibody production on their T and B cells – two types of white blood cells – against alpha-lactalbumin, the molecule targeted by the vaccine.

Researchers said the only side effect observed was irritation at the injection site.

Angelina Jolie at the Cannes Film Festival.
Jolie had her breasts removed in 2013 after she found out she had the genetic mutation for triple negative breast cancer. FilmMagic

“It’s a very new mechanism and we think that if this works and is able to prevent cancer, then we can perhaps eliminate breast cancer as a disease, just like we’ve done for polio and various other infectious diseases,” Kumar told The Post.

Phase two, set to begin next year, will test the vaccine on a larger group, and for other types of breast cancer.

“Cancer vaccines have been very, very difficult to develop,” he added. “There’s never been a successful true cancer vaccine.”

Dr. Amit Kumar in a suit sitting on a couch for a photo
Kumar hopes the vaccine eradicates the disease by 2030. Courtesy of Anixa Biosciences

Unlike vaccines for infectious diseases, which target organisms foreign to the body like viruses, cancer is a different ballgame since it grows out of a person’s own cells.

“The cancer cells arise out of your own healthy cells … so the immune system is not able to see very distinctly that the cancer cell is a bad cell,” said Kumar.

Research in cancer vaccines has mostly targeted proteins that show up in higher concentration on cancer cells — but that’s resulted in the immune system also attacking healthy organs that display the protein.

Researcher conducting a breast cancer vaccine experiment in a lab.
Researchers measured antibody production in the blood of women who participated in the trial. Courtesy of Cleveland Clinic

But something unique to breast cancer is one of the proteins in the cancerous cells — the lactation protein alpha-lactalbumin — is not present during most of a woman’s life, except in pregnancy and breastfeeding.

So a scientist at the Cleveland Clinic had the idea in 2018 to target alpha-lactalbumin and vaccinate women not planning to have any more children, which led to the trial.

“It’s a very new mechanism and we think that if this works and is able to prevent cancer, then we can perhaps eliminate breast cancer as a disease, just like we’ve done for polio and various other infectious diseases,” Kumar told The Post.

Woman undergoing a 3D mammogram.
One in eight women will get breast cancer at some point in her life, making it the most prevalent cancer in the world. Viacheslav Yakobchuk – stock.adobe.com

The study, which was seen as breakthrough medical research, is receiving funding from the US Department of Defense. Kumar hopes it’s not impacted by the current federal funding cuts.

“There’s a lot of uncertainty,” he admitted.

Researchers plan to present their findings to the White House this year.

The post Breakthrough vaccine could eradicate breast cancer, shows 75% immune response in trial appeared first on New York Post.

Tags: breast cancerDepartment of DefenseResearchTrialsvaccines
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