9 Best Wrinkle Fillers, Tested and Recommended by Dermatologists

As a beauty writer who consistently goes for in-office treatments like Botox, I’m also constantly testing the best wrinkle fillers to extend the time in between my visits. Through years of experimenting, I’ve figured out which ingredients (think: retinols, peptides, hyaluronic acid, and more) are most effective—both short and long-term.

“Topical wrinkle fillers are skin care products that temporarily plump up the skin to decrease the appearance of lines,” says Connie Yang, MD, a board-certified dermatologist based in NYC. They typically come in creams, gels, or serums, and “they work by filling in wrinkles with ingredients like silicones, plumping the skin with hydrators such as hyaluronic acid, and blurring imperfections using light-reflecting particles,” says Pooja Rambhia, MD, a board-certified dermatologist at UnionDerm in NYC. “Some also include peptides or retinol to support collagen production over time.”

To narrow down the best options out there, we consulted with several dermatologists and tried the most highly-rated products on the market firsthand. Our pick is Dr Dennis Gross DermInfusions Fill + Repair Serum thanks to its ability to both instantly fill fine lines and prevent wrinkles in the long-run. But if you’re looking for a budget option, or a specialized product for deep wrinkles or under-eye crepiness, there are options for you, too.

The best wrinkle fillers, at a glance

Best Overall Wrinkle Filler: Dr Dennis Gross DermInfusions Fill + Repair Serum

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Original photo from Taryn Brooke testing Dr. Dennis Gross DermInfusions Fill + Repair Serum

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Dr. Dennis Gross DermInfusions Fill + Repair Serum

$75

Nordstrom

$75

Amazon

$75

Sephora

Key Ingredients: Hyaluronic acid, peptides, niacinamide, ectoin
Size: 1 oz.

Pros: Plumps and hydrates
Cons: Requires consistent application for full results

Dr. Dennis Gross DermInfusions Fill + Repair Serum is our best overall pick because it covers all the necessary skin care basics: it firms, plumps, fills, and most importantly, it helps to restore the skin’s moisture barrier, which is crucial to maintaining a youthful look. Not to mention, it contains four weights of hyaluronic acid, which “means that you’re getting different layers of penetration into the epidermis for a plumping effect,” says Daniel Belkin, MD, a board-certified dermatologist and dermatologic surgeon based in NYC. Plus, it has ectoin, a powerful skin protectant that not only strengthens the skin’s moisture barrier but prevents transepidermal water loss, which is key for fighting aging.

“Not only does it soothe my skin after application, but it fills in any fine lines on my forehead and notably plumps the area around my eyes. Though I’ve only been using the serum for about two weeks, I usually only use it in the morning as my serum step, and it leaves my skin looking radiant and fuller, and I simply follow it with my moisturizer and SPF.” Glamour contributor Taryn Brooke says the serum has also helped her maintain her “daily no makeup look.”

Best for Botox Alternative Wrinkle Filler: Skinceuticals P-TIOX Serum

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Original photo from Taryn Brooke testing Skinceuticals P-TIOX Serum

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Skinceuticals P-TIOX Serum

$148

Dermstore

$148

Blue Mercury

Key Ingredients: Advanced peptide complex (hexapeptide and dipeptide), PHA, niacinamide, laminaria extract
Size: 1 oz.

Pros: Lightweight serum, adds shine and bounce to the skin
Cons: Pricey for the amount of product

“Though I have been getting Botox for years, I’ve found that each time I get it (about four times a year) it wears off a little faster each time,” says Brooke.“To help extend the life of my ‘tox and keep my forehead as smooth as possible in between appointments, I started using Skinceuticals P-TIOX Serum after my daily vitamin C serum in the morning and before my retinol products at night.”

This peptide-powered serum made of Skinceuticals’ proprietary blend of advanced peptides and synergistic actives, such as PHA, niacinamide, and laminaria extract, is clinically proven to help reduce fine lines, leaving your skin with a glass-like radiance. “I can confidently say that not only have my expression lines been reduced, but I now wait a little longer between my Botox appointments. I also love how it’s improved the texture of my skin and added a healthy bounce.”

Best for Deep Wrinkles: Strivectin Anti-Wrinkle Peptide Plump Line Filling Bounce Serum

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StriVectin Anti-Wrinkle Peptide Plump Line Filling Bounce Serum

$89

Amazon

$89

Nordstrom

$89

Ulta

Key Ingredients: Alpha-3 Peptide, red algae extract, turmeric root extract
Size: 1 oz.

Pros: Reduces deep wrinkles
Cons: Takes time to see full results

This product passes the line-filling test with flying colors. “I used this product for a week, and whether it ironed out my wrinkles or not, my skin feels bouncy and looks bright. I love the way it looks, and yes, the forehead lines, which the brand says the serum specifically helps, appear more faint. I would dab on the product in a targeted way, on the problem areas, let it absorb, then put on a layer of moisturizer,” says Glamour contributor Charlotte Twine. Though she says that the wrinkles around her mouth looked about the same, she’s “pleased with the results overall” and plans to make the serum a part of her regular routine.

Best for Eyes: Peter Thomas Roth Peptide Skinjection Fill + Fix Under Eye Cream

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Original photo from Taryn Brooke testing Peter Thomas Roth Peptide Skinjection Fill + Fix Under Eye Cream

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Peter Thomas Roth Peptide Skinjection Fill + Fix Under Eye Cream

$45

Sephora

$45

Ulta

$45

Amazon

Key Ingredients: Peptides, Juveneye CLR, hyaluronic acid
Size: 0.5 oz.

Pros: Smooths out fine lines under the eyes and evens out dark circles almost immediately
Cons: Temporary effect

“Sometimes there are places that Botox and filler just won’t reach, so to help smooth out my undereyes for the day, I reach for this cream,” says Brooke.“I use it every morning and it not only refreshes the appearance of my tired eyes (because honestly, who’s able to get a full eight hours these days?), but it also helps to color-correct and brighten my under eye area.”. The best part, she adds, is the cooling metal tip that instantly wakes up your eyes and gently spreads the product. “There are times I will use the product alone, without makeup, or I’ll use it prior to applying my foundation. I love it,” she says.

Best Retinol Wrinkle Filler: RoC Retinol Correction Deep Wrinkle Filler

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Original photo from Jenifer Calle testing RoC Retinol Correction Deep Wrinkle Filler

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RoC Retinol Correction Deep Wrinkle Filler

$30 $22

Amazon

$30

Ulta

$22

Walmart

Pros: Diminishes the look of fine lines
Cons: Full results with consistent use over time
Key Ingredients: Retinol, glycerin
Size: 1 oz.

Glamour senior commerce editor Jenifer Calle swears by this RoC product. “Now that I’m in my 30’s retinol has come into play a lot more in my skin care routine, and this wrinkle filler is one of the best creams I’ve tried. I’ve noticed that my skin isn’t as plump and firm as it used to be. Since I’m constantly squinting or looking at my computer, I’ve also noticed I formed ‘elven’ lines on my forehead area. I’ve been using this RoC Retinol Correction Deep Wrinkle Filler on that area of my brows and it significantly reduced the appearance of those lines. I add it to my routine about 1-2 a week and it keeps that area smooth.”

Best Multi-Purpose Wrinkle Filler: Lawless Forget the Filler Skin-Plumping Line-Smoothing Perfecting Cream

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Original photo from Alanna Martine Kilkeary testing Lawless Forget the Filler Skin-Plumping Line-Smoothing Perfecting Cream

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Lawless Forget the Filler Skin-Plumping Line-Smoothing Perfecting Cream

$52

Sephora

Key Ingredients: Maxi-Youth, octapeptide-3, hexapeptide-8
Size: 1.7 oz.

Pros: Works immediately and great under makeup
Cons: Takes time and consistency for full results

A moisturizer that plumps and also works perfectly as a makeup primer? Say less. “This ultra-soothing pink cream makes my skin look and feel plumped and refreshed almost instantly after application. It’s packed with peptides that help soften fine lines and add bounce and resilience to the skin, and I’ve definitely noticed a difference after using it for a few weeks. The fine lines on my forehead are less apparent and my skin looks tighter and even-toned, not to mention, this cream is perfect for creating a smooth canvas for makeup, too.” says Glamour commerce writer Alanna Martine Kilkeary.

Best Instant Wrinkle Filler: Peter Thomas Roth Instant FIRMx Temporary Face Tightener

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Original photo from Taryn Brooke testing Peter Thomas Roth Instant Firmx Temporary Face Tightener

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Peter Thomas Roth Instant Firmx Temporary Face Tightener

$49

Sephora

$49

Amazon

$49 $35

Ulta

Key Ingredients: Silicone, vitamins C and E, pro vitamin B5
Size: 3.4 oz.

Pros: Goes on smoothly and instantly tightens
Cons: Filling is temporary

A cult favorite, “this has become my go-to makeup primer as of late,” says Brooke. Formulated with silicones and skin nourishing antioxidants vitamins C and E, the product offers immediate tightening within five minutes of application. The silicone in the formulation “form[s] a thin film over the skin that can fill in the lines and smooth out uneven texture–this is why they’re often found in primers to provide a smooth base for your makeup,” says Dr. Yang.

Though she doesn’t use it every day, Brooke says she reaches for this product when she wants her makeup to look extra smooth on a night out. “I mostly love the tightening effect that it has on my forehead and around my eyes. The only catch is that you have to make sure all your products, such as your moisturizer, are fully absorbed before you even attempt to use this,” she says. “After your face is dry, slowly and smoothly apply the face tightener, keeping your face still and allow it to try before you apply your makeup. Et Voila! Any trouble spots on your face are smooth and your makeup looks flawless,” says Brooke.

Best Budget: No7 Instant Illusion Wrinkle Filler

No7 Instant Illusion Wrinkle Filler

$17

Amazon

$16

Walmart

Key Ingredients: Silicone, glycerin
Size: 1 oz.

Pros: Works instantly
Cons: Results are temporary

Thanks to silicone, a noted wrinkle-filling ingredient, this product smooths t fine lines and wrinkles instantly, without the hefty price tag. Glamour contributor Twine loved this one but said that it required a little practice with the application to get the best effect. “On my first try, I was astounded —it erased some crinkles and crepiness around my eyes, and the fine lines in my ‘11’ and on my forehead, instantly. Kind of like spackle!” Twine says. “However, there are a couple of caveats. When the product dries, it has kind of a white, chalky effect. So I really had to practice in order to not put too much on. Also, you have to use a pretty deft, light patting motion in order to get the product in the wrinkle itself, then gently smooth away the excess. And I’m not sure how long it lasted throughout the day? My face is expressive (honestly, I like my smile lines! Yay!), so I noticed the crinkles weren’t as covered by the end of the day. The blurring effect is too good to pass up.”

Best Wrinkle Filler for Lip Lines: Alastin Skincare HA Immerse Serum

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Original photo from Taryn Brooke testing Alastin Skincare HA Immerse Serum

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Alastin Skincare HA Immerse Serum

$127

Amazon

Key Ingredients: Octapeptide-45, silver mushroom extract, hexapeptide-11
Size: 1 oz.

Pros: Instant hydration and plump
Cons: Pricey for the amount of product

A dermatologist favorite, this product penetrates deep into the skin, increasing the skin’s hyaluronic acid levels, aiding in long-term hydration and plumping. “It gave my skin an instant boost of hydration, smoothing out my fine forehead lines that remind me that it’s time for my next Botox appointment,” says Brooke “Having just gone for an ablative laser treatment, I love that the serum is suitable for post-procedure skin, and I very much appreciated it because I was unable to use any of my other actives, so I’m able to see the plumping effects of the serum even more.” Brooke says the serum felt lightweight and she saw small i improvements in her skin’s clarity and radiance after using it daily for almost a week.