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What is mitochondrial dysfunction? Health issue Surgeon General nom Dr. Casey Means says is at the root of chronic illness

February 25, 2026
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What is mitochondrial dysfunction? Health issue Surgeon General nom Dr. Casey Means says is at the root of chronic illness

Almost every American has some degree of metabolic dysfunction — at least that’s what President Trump’s nominee for surgeon general would say.

Dr. Casey Means, a graduate of the Stanford School of Medicine and lapsed functional medicine practitioner, began her Senate confirmation hearing on Wednesday to become “America’s doctor,” putting her health views under a microscope.

The MAHA leader, social media darling and entrepreneur soon shared her biggest goal for the role: “moving towards a real healthcare system and not just a reactive sick care system — which is of course also going to lower costs monumentally and unburden American taxpayers and doctors.”

Casey Means testifying before a Senate Health, Education, Labor, and Pensions Committee confirmation hearing.
Dr. Casey Means is testifying today at a Senate Health, Education, Labor, and Pensions Committee confirmation hearing to become Surgeon General. REUTERS

Means’ skepticism of conventional medicine and big pharma have earned her criticism from the medical community, particularly around her opinions on raw milk, her murky stance on birth control and contraception and her questioning of the safety of certain vaccines, especially Hepatitis B in infants.

But her strongest advocacy — some of which has been widely panned and some of which has been deemed common sense — has been centered around what she believes is the hidden culprit of many of this nation’s most common and confounding health concerns, ranging from cancers to mental illnesses.

“The reality is that the majority of the diseases that are plaguing our country and more and more our globe are diseases that are chronic illnesses based on lifestyle and dietary decisions,” she said on an episode of The B.rad Podcast. “And these daily decisions that have stacked up day after day, year over year, have led people towards chronic disease.”

She even wrote a book on the subject, “Good Energy: The Surprising Connection Between Metabolism and Limitless Health,” with her brother Calley, a White House health advisor.

In it, she claims “mitochondrial dysfunction” is the root cause of most metabolic conditions and chronic illnesses.

What is mitochondrial dysfunction?

Mitochondria are often referred to as the “powerhouses” of the cells. They create energy for cells to function, allowing our bodies to do everything from walking and breathing to thinking and feeling.

Speaking to NPR about the book, Means blamed a slew of modern health epidemics on our failing mitochondria.

Mitochondrial dysfunction, or “underpowered cells” as she calls it, is the reason why, according to a 2022 study she cited, only 6.8% of Americans have “optimal metabolic health.”

Dr. Casey Means and journalist Megyn Kelly smiling.
Mitochondrial dysfunction is to blame for most chronic diseases, Means argues. AP

“What the science is telling us is that most of the chronic symptoms and conditions that are affecting Americans across the lifespan are rooted in metabolic dysfunction,” she told NPR, “which is a core problem in how our bodies and our cells actually make energy to power themselves.”

She offered a visual to help paint the picture: “We’re talking about the trunk of the tree of American health care being metabolic dysfunction and all the branches being the different symptoms and diseases that we’re so familiar with, [including] Type 2 diabetes, obesity, Alzheimer’s, dementia, cancer, chronic kidney disease…”

Means believes these mitochondrial disruptions are coming at us from all directions, including what we eat, how we sleep, products we use and workplace conditions. 

“A big question people might have is why now, all of a sudden, are mitochondria under siege? And the reason is our environment has been changing at such a rapid pace over the last hundred years or so,” she said.

Illustration of two mitochondria, membrane-enclosed cellular organelles, which produce energy.
Mitochondria are the “powerhouses” of the cells. Dr_Microbe – stock.adobe.com

Most people would agree that our lifestyles and environments are constructed in such a way that we don’t get enough of the right kind of movement or rest, and we don’t get enough exposure to the right kind of light or temperature. Meanwhile, we’re exposed to more toxins and chemicals, and experiencing more stress. 

Means argues this is a formula for mitochondrial dysfunction in our cells, which then puts pressure on our organs and ultimately leads to disease.

What does the research say?

Some of these theories bear out in clinical studies, like recent findings out of Europe linking disruptions to the circadian rhythm to metabolic diseases like diabetes. 

The researchers involved found that regular exposure to natural light led to “more stable blood glucose levels and an overall improvement” in the metabolic health of all 13 people who participated in the study.

There are plenty of similar one-off studies that look at a single lifestyle or environmental factor and its effects on metabolic health, but few researchers and practitioners look at the holistic impact of multiple compounding factors on a variety of biomarkers the way Means insists they should.

Book cover for
In her book, “Good Energy,” Means writes about the different lifestyle and environmental factors that contribute to our “underpowered cells.” Casey Means

As far as solutions go, what Means recommends is hardly a cause for raised eyebrows.

First, have your biomarkers checked by a doctor. This includes fasting glucose, triglycerides, HDL cholesterol, hemoglobin A1C, waist circumference and blood pressure, she told NPR.

Second, eat only whole, unprocessed foods for six weeks. (Or incorporate them into your diet as much as possible.)

Third, take at least 7,000 steps per day, or go for a short (like, around-the-block short) walk every 45 minutes, also for six weeks.

Then check your biomarkers again.

While there’s room for debate about whether these steps will “transform” your mitochondrial efficacy in as little as six weeks as she suggests, it’s hard to argue with the call for fewer processed foods and more daily movement.

Though Means has denounced the medical system for trying to solve every problem with a pill or a shot, her book does seem to be selling a “silver bullet” mentality of its own, with a blurb that reads: “Nearly every health problem we face can be explained by how well the cells in our body create and use energy.” She is also the founder of at-home glucose-monitoring company Levels. 

Her confirmation hearing this week has reenergized criticism for what many in the medical field feel is her history of demonizing doctors and promoting vigilante health care.

In her conversation with NPR, she didn’t entirely deny this stance. 

“This is a controversial statement, but I feel comfortable saying it,” she said. “You don’t need to trust any health influencers. You don’t even need to trust your doctor. You actually can trust yourself.”

The post What is mitochondrial dysfunction? Health issue Surgeon General nom Dr. Casey Means says is at the root of chronic illness appeared first on New York Post.

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